Christopher M. Snyder, PhD
Professor
Contact
233 South Tenth Street
Bluemle Life Sciences Building, Room 730
Philadelphia, PA 19107
215-503-2543
215-923 7145 fax
Featured Links
Christopher M. Snyder, PhD
Professor
Education
PhD, University of Colorado Health Sciences University
Fellowship
Oregon Health Sciences University
Most Recent Peer-Reviewed Publications
- Multiple and Consecutive Genome Editing Using i-GONAD and Breeding Enrichment Facilitates the Production of Genetically Modified Mice
- Mechanisms of antiviral cytotoxic cd4 t cell differentiation
- Inhibitory Molecules PD-1, CD73 and CD39 Are Expressed by CD8+ T Cells in a Tissue-Dependent Manner and Can Inhibit T Cell Responses to Stimulation
- Hematopoietic cell-mediated dissemination of murine cytomegalovirus is regulated by NK cells and immune evasion
- STING sensing of murine cytomegalovirus alters the tumor microenvironment to promote antitumor immunity
Expertise & Research Interests
Our lab is interested in understanding how T cells respond to chronic antigen stimulation during persistent viral infections. To this end, our lab investigates cytomegalovirus (CMV), a ubiquitous herpesvirus that infects most people world-wide and persists for life. In healthy individuals CMV is continuously controlled by the immune system and causes little or no pathology. However, this constant control of CMV results in the slow accumulation of virus-specific T cells to extraordinary levels. On average, CMV-specific T cells comprise 4% to 5% of all T cells in infected individuals. These large numbers of CMV-specific T cells are thought to be vital for maintaining control of the infection and immunocompromised individuals can develop severe CMV-caused morbidity and mortality. However, the mechanisms by which these T cells are generated and maintained are not understood. Additionally, we don’t understand what effect these cells might have on the immune system as a whole. This may be particularly relevant during ageing as CMV-specific populations become increasingly dominant. Indeed, CMV infection has been linked to the development of an “Immune Risk Phenotype” that describes people who respond poorly to new infections or vaccines. To study CMV, we use murine cytomegalovirus (MCMV), a homologue of human CMV (HCMV) and a natural mouse pathogen. Like HCMV, infection of mice with MCMV results in the slow accumulation of functional, viral-specific T cells over time and it is this process that forms the foundation of our research interest. Currently we focus on two broad questions: 1) What are the mechanisms by which CMV-specific T cell are primed, accumulate and persist and 2) How does the presence of these population impact the overall generation and homeostasis of memory T cells specific for other infections.