Division of Rheumatology
Leadership
- Director, Division of Rheumatology
- Director, Rheumatology Fellowship Program
- Magee Professor in Medicine
Contact
211 South Ninth Street
Suite 210
Philadelphia, PA 19107
- 215-955-2820
- 215-923-7885 (fax)
Research Activities
Kiriakidou Lab
microRNAs in Systemic Lupus Erythematosus
RNA interference (RNAi) operates as a mechanism of innate immunity in plants, drosophila and C. elegans and depends on double stranded RNA and proteins of the Argonaute family. RNAi, programmed by exogenous small RNAs, is a powerful tool for gene-specific studies. The microRNA pathway intersects with the RNAi pathway and regulates gene expression in plants and animals. Animal microRNAs bind directly to Argonaute proteins (Ago1-4), providing target specificity to the regulatory function of Ago complexes. Research in the Kiriakidou lab focused on the biology of animal Ago proteins by studying the expression, regulation and function of animal Agos in human and mouse cells, mouse models and in vitro systems.
MicroRNAs are involved in numerous biological processes, and their expression is differentially regulated in human disease. Systemic Lupus Erythematosus (SLE, lupus) is a prototype systemic autoimmune disease characterized by autoantibody production and tissue deposition of immune complexes. Immunopathology in lupus is characterized by aberrant B and T cell functions. We are studying the role of microRNAs in pathways contributing to disease-specific B and T cell phenotypes and organ damage in SLE using microRNA KO models and mouse lupus models (congenic and induced). We also use synthetic inhibitors for microRNA silencing in vivo, to complement our genetic studies and to investigate potential use of microRNA.
Lab Members
Barry Garchow, PhD
Recent Publications
- Valemetostat monotherapy in patients with relapsed or refractory non-Hodgkin lymphoma: a first-in-human, multicentre, open-label, single-arm, phase 1 study
- Heart rate variability wrist-wearable biomarkers identify adverse posttraumatic neuropsychiatric sequelae after traumatic stress exposure
- Neighborhood Resources Associated with Psychological Trajectories and Neural Reactivity to Reward after Trauma
- Characterizing Long COVID in Children and Adolescents
- ABCG2-Expressing Clonal Repopulating Endothelial Cells Serve to Form and Maintain Blood Vessels
- Sex Differences in Response Inhibition–Related Neural Predictors of Posttraumatic Stress Disorder in Civilians With Recent Trauma
- Letter to the editor in response to article "Use of statins in patients with established idiopathic inflammatory myopathies"
- Primary anastomosis with diverting loop ileostomy vs. Hartmann’s procedure for acute diverticulitis: what happens after discharge? Results of a nationwide analysis
- Efficacy and Safety of Thermal Ablation after Endoscopic Mucosal Resection: A Systematic Review and Network Meta-Analysis
- Hypophysitis Secondary to Small Vessel ANCA Vasculitis Treated With Rituximab
- Core outcome measurement set for research and clinical practice in post-COVID-19 condition (long COVID) in children and young people: an international Delphi consensus study “PC-COS Children”
- Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
- Associations of alcohol and cannabis use with change in posttraumatic stress disorder and depression symptoms over time in recently trauma-exposed individuals
- Two Decades Since the Unequal Treatment Report: The State of Racial, Ethnic, and Socioeconomic Disparities in Elective Total Hip and Knee Replacement Use
- Comparison of Reference and Biosimilar Medications for Pediatric Noninfectious Uveitis
- Nodular scleroderma: Characterization of a distinct clinical phenotype
- Does the Impact of COVID-19 on Patients With Systemic Sclerosis Change Over Time?
- Low utilization of statins in patients with dermatomyositis/polymyositis and hyperlipidemia: a multicenter USA-based study (2013–2023)
- Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort
- Cartilage-specific Sirt6 deficiency represses IGF-1 and enhances osteoarthritis severity in mice