T32 Training Program in Cellular, Biochemical, & Molecular Sciences
Leadership
Positions:
- Co-Director, T32 Training Program in Cellular, Biochemical, & Molecular Sciences
- Professor
Email:
[email protected]
Positions:
- Co-Director, T32 Training Program in Cellular, Biochemical, & Molecular Sciences
- Thomas Eakins Endowed Professor
Email:
[email protected]
Contact
233 S. 10th Street
Bluemle Life Sciences Building
Philadelphia, PA 19107
Email:
[email protected]
Contact Number(s):
Publications
- Aumiller JL, Wedegaertner PB. Disruption of the interaction between mutationally activated Gαq and Gβγ attenuates aberrant signaling. J Biol Chem. 2023 Feb;299(2):102880. doi: 10.1016/j.jbc.2023.102880. Epub 2023 Jan 7. PMID: 36626984; PMCID: PMC9926304.
- Randolph CE, Dwyer MB, Aumiller JL, Dixon AJ, Inoue A, Osei-Owusu P, Wedegaertner PB. Enhanced membrane binding of oncogenic G protein αqQ209L confers resistance to inhibitor YM-254890. J Biol Chem. 2022 Nov;298(11):102538. doi: 10.1016/j.jbc.2022.102538. Epub 2022 Sep 27. PMID: 36174676; PMCID: PMC9626947.
- DeDreu J, Le PM, Menko AS. The ciliary zonules provide a pathway for immune cells to populate the avascular lens during eye development. Exp Biol Med (Maywood). 2022 Dec; 247(24):2251-2273. doi: 10.1177/15353702221140411. Epub 2023 Jan 12. PMID: 36633170; PMCID: PMC9899985.
- Gamlen HA, Romer-Seibert JS, Lawler ME, Versace AM, Goetz ML, Yang F, Guryanova OA, Palmisiano N, Meyer SE. miR-196b-TLR7/8 signaling axis regulates innate immune signaling and myeloid maturation in DNMT3A-mutant AML. Clin Cancer Res 2022;28:4574–86. doi: 10.1158/1078-0432.CCR-22-1598 PMID: 35943291 PMCID: PMC9588567
- Barton, JR, Londregan, AK, Alexander, TD, Entezari, AA, Bar-Ad, S, Cheng, L, … Waldman, SA (2023). Intestinal neuropod cell GUCY2C regulates visceral pain. J Clin Invest. 2023;133(4):e165578. doi: 10.1172/JCI165578 PMID: 36548082
- Brumer RP, Corrêa-Velloso JC, Thomas SJ, Sandiford OA, Thomas AP, Bartlett PJ. Short-term high fat diet feeding of mice suppresses catecholamine-stimulated Ca2+ signalling in hepatocytes and intact liver. J Physiol. 2023 Mar 2. Epub ahead of print. doi: 10.1113/JP283691 PMID: 36864773
- DeDreu J, Basta MD, Walker JL, Menko AS. Immune Responses Induced at One Hour Post Cataract Surgery Wounding of the Chick Lens. Biomolecules. 2023 Nov 4;13(11):1615. doi: 10.3390/biom13111615. PMID: 38002297; PMCID: PMC10668984.
- Roy P, Walter Z, Berish L, Ramage H, McCullagh M. Motif-VI loop acts as a nucleotide valve in the West Nile Virus NS3 Helicase. Nucleic Acids Res. 2024 Jul 22;52(13):7447-7464. doi: 10.1093/nar/gkae500. PMID: 38884215; PMCID: PMC11260461.
- Dwyer MB, Aumiller JL, Wedegaertner PB. Going rogue: mechanisms, regulation, and roles of mutationally activated Gα in human cancer. Mol Pharmacol. 2024 Aug 26:MOLPHARM-MR-2023-000743. doi: 10.1124/molpharm.124.000743. Epub ahead of print. PMID: 39187387.
- Han A, Mukha D, Chua V, Purwin TJ, Tiago M, Modasia B, Baqai U, Aumiller JL, Bechtel N, Hunter E, Danielson M, Terai M, Wedegaertner PB, Sato T, Landreville S, Davies MA, Kurtenbach S, Harbour JW, Schug ZT, Aplin AE. Co-Targeting FASN and mTOR Suppresses Uveal Melanoma Growth. Cancers (Basel). 2023 Jun 30;15(13):3451. doi: 10.3390/cancers15133451. PMID: 37444561; PMCID: PMC10341317.
- Thomas SJ, Ghosh B, Wang Z, Yang M, Nong J, Severa J, Wright MC, Zhong Y, Lepore AC. Hepatocyte Growth Factor Delivery to Injured Cervical Spinal Cord Using an Engineered Biomaterial Protects Respiratory Neural Circuitry and Preserves Functional Diaphragm Innervation. J Neurotrauma. 2024 Aug 12. doi: 10.1089/neu.2024.0084. Epub ahead of print. PMID: 39078323.
- Montoya B, Melo-Silva CR, Tang L, Kafle S, Lidskiy P, Bajusz C, Vadovics M, Muramatsu H, Abraham E, Lipinszki Z, Chatterjee D, Scher G, Benitez J, Sung MMH, Tam YK, Catanzaro NJ, Schäfer A, Andino R, Baric RS, Martinez DR, Pardi N, Sigal LJ. mRNA-LNP vaccine-induced CD8+ T cells protect mice from lethal SARS-CoV-2 infection in the absence of specific antibodies. Mol Ther. 2024 Jun 5;32(6):1790-1804. doi: 10.1016/j.ymthe.2024.04.019. Epub 2024 Apr 11. PMID: 38605519; PMCID: PMC11184341.
- Michel-Flutot P, Cheng L, Thomas SJ, Lisi B, Schwartz H, Lam S, Lyttle M, Jaffe DA, Smith G, Li S, Wright MC, Lepore AC. PTEN inhibition promotes robust growth of bulbospinal respiratory axons and partial recovery of diaphragm function in a chronic model of cervical contusion spinal cord injury. Exp Neurol. 2024 Aug;378:114816. doi: 10.1016/j.expneurol.2024.114816. Epub 2024 May 22. PMID: 38789023; PMCID: PMC11200215.
- Urban MW, Charsar BA, Heinsinger NM, Markandaiah SS, Sprimont L, Zhou W, Brown EV, Henderson NT, Thomas SJ, Ghosh B, Cain RE, Trotti D, Pasinelli P, Wright MC, Dalva MB, Lepore AC. EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS. Elife. 2024 Jan 15;12:RP89298. doi: 10.7554/eLife.89298. PMID: 38224498; PMCID: PMC10945582.