Rajanikanth Vadigepalli, PhD
Professor, Department of Pathology & Genomic Medicine
Co-Director, Cell Biology & Regenerative Medicine PhD Program
Contact
1020 Locust Street
314 Alumni Hall
Philadelphia, PA 19107
215-955-0576
215-503-2636 fax
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Rajanikanth Vadigepalli, PhD
Professor, Department of Pathology & Genomic Medicine
Co-Director, Cell Biology & Regenerative Medicine PhD Program
Expertise & Research Interests
Work in Dr. Vadigepalli's lab is directed at understanding the regulatory network dynamics driving the cellular adaptive processes in mammalian pathophysiology. Though cross-disciplinary collaborative projects, we study signaling and gene regulatory networks in : central cardiorespiratory control circuits adversely adapted in hypertension, alcohol toxicity on liver repair and regeneration, and abnormal stem cell differentiation in the context of fetal alcohol spectrum disorders. We use computational modeling, systems engineering and bioinformatics approaches to complement high-throughout experimentation. Trainees in the lab have the opportunity to gain experience in the computational modeling and analysis including transcriptional profiling, genome-wide localization, and next generation sequencing approaches; and experimental methods for high-throughout validation of gene regulatory mechanisms.
Visit the Vadigepalli Laboratory
Education
PhD, University of Delaware, Chemical Engineering - 2001
BTech, Indian Institute of Technology Madras, Chemical Engineering - 1996
Publications
- Integrated transcriptomics and histopathology approach identifies a subset of rejected donor livers with potential suitability for transplantation
- Neuromodulatory co-expression in cardiac vagal motor neurons of the dorsal motor nucleus of the vagus
- Dynamic dysregulation of transcriptomic networks in brainstem autonomic nuclei during hypertension development in the female spontaneously hypertensive rat
- Nonlinear Model Predictive Control of Vagal Nerve Stimulation to regulate hemodynamic variables
- Closed-loop modeling of central and intrinsic cardiac nervous system circuits underlying cardiovascular control