Rajanikanth Vadigepalli, PhD
Professor
Vice Chair for Research
Contact
1020 Locust Street
Jefferson Alumni Hall, Suite 314C
Philadelphia, PA 19107
215-955-0576
215-503-2636 fax
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Rajanikanth Vadigepalli, PhD
Professor
Vice Chair for Research
Research & Clinical Interests
We are interested in understanding the operational principles of mammalian tissue plasticity, renewal, repair and regeneration. A key goal is to develop novel clinical interventions and decision-support systems for regenerative medicine. Our transdisciplinary systems biology strategy integrates computational modeling, systems engineering, bioinformatics, functional genomics, high-dimensional data analysis, and single cell scale experimentation. Ongoing collaborative projects focus on liver repair and regeneration, alcoholic liver disease, brainstem neuroinflammation and neuroimmune processes leading to hypertension, cell fate regulation underlying developmental defects, and network modeling of renewal and regeneration in multiple mammalian tissues.
Click here for Vadigepalli Laboratory.
Education
PhD, Chemical Engineering, University of Delaware (2001)
BTech, Chemical Engineering, Indian Institute of Technology Madras (1996)
Most Recent Peer-Reviewed Publications
- Integrated transcriptomics and histopathology approach identifies a subset of rejected donor livers with potential suitability for transplantation
- Neuromodulatory co-expression in cardiac vagal motor neurons of the dorsal motor nucleus of the vagus
- Dynamic dysregulation of transcriptomic networks in brainstem autonomic nuclei during hypertension development in the female spontaneously hypertensive rat
- Nonlinear Model Predictive Control of Vagal Nerve Stimulation to regulate hemodynamic variables
- Closed-loop modeling of central and intrinsic cardiac nervous system circuits underlying cardiovascular control