We are seeking to understand the molecular cell biology regulating how circulating blood platelets contribute to hemostasis and thrombosis, and to apply this understanding to modulate platelet function in various contexts. Our research program spans molecular studies of control of platelet gene expression, the cell biological outcomes of this regulation, physiological studies of platelet function, and development of tools for pre-clinical applications in health and disease.
Lawrence Goldfinger, PhD
Professor, Department of Medicine
Director, Molecular Physiology & Translational Medicine PhD Program
Contact Information
Jefferson Alumni Hall
1020 Locust Street
394 JAH
Philadelphia, PA 19107
Professor, Department of Medicine
Director, Molecular Physiology & Translational Medicine PhD Program
Research & Interests:
Education
PhD, Carnegie Mellon University
Publications
- Argonaute2 modulates megakaryocyte development and sex-specific control of platelet protein expression and reactivity
- Transcription factor RUNX1 regulates coagulation factor XIII-A (F13A1): decreased platelet-megakaryocyte F13A1 expression and clot contraction in RUNX1 haplodeficiency
- Phosphatidylserine-blocking nanoparticles inhibit thrombosis without increased bleeding in mice
- Altered platelet-megakaryocyte endocytosis and trafficking of albumin and fibrinogen in RUNX1 haplodeficiency
- Plasma growth factors maintain constitutive translation in platelets to regulate reactivity and thrombotic potential