Deepak Deshpande, DVM, PhD
Professor of Medicine, Division of Pulmonary, Allergy & Critical Care Medicine
Contact Information
1020 Locust Street
Room 543B
Philadelphia, PA 19107
215-955-3305
215-503-5731 fax
Professor of Medicine, Division of Pulmonary, Allergy & Critical Care Medicine
Research & Clinical Interests
My laboratory studies intracellular signaling regulating contraction, relaxation and proliferation of airway smooth muscle with particular emphasis on G protein coupled receptor mediated signaling. Airway smooth muscle is the principle contractile component of airways, and contraction and relaxation of ASM regulate airway diameter. Any alteration in ASM function results in bronchoconstriction and difficulty in breathing. Therefore, ASM acts as a primary therapeutic target in obstructive airway diseases such as asthma and COPD. Delineating novel receptors and signaling mechanisms that regulate ASM function would provide basis for developing newer and better drugs to treat asthma. Current projects are found on my Research Site.
Education
PhD, College of Veterinary Medicine, University of Minnesota, 2004
MS, Veterinary College, University of Agricultural Sciences, Bangalore, India, 1997
DMV, Veterinary College, University of Agricultural Sciences, Bangalore, India, 1994
Publications
- CD38/cADPR-mediated calcium signaling in a human myometrial smooth muscle cell line, PHM1
- Immunoactive signatures of circulating tRNA- and rRNA-derived RNAs in chronic obstructive pulmonary disease
- Molecular mechanism of bitter taste receptor agonist-mediated relaxation of airway smooth muscle
- Diacylglycerol kinase is a keystone regulator of signaling relevant to the pathophysiology of asthma
- Superoxide Anions Inhibit Intracellular Calcium Response in Porcine Airway Smooth Muscle Cells
Professional Societies
- American Thoracic Society