Tung Chan, PhD
Assistant Professor of Medicine, Division of Pulmonary, Allergy & Critical Care Medicine
Contact Information
Assistant Professor of Medicine, Division of Pulmonary, Allergy & Critical Care Medicine
Research & Clinical Interests
Targeting Akt Kinase and PKA Dephosphorylation Mechanisms To Heal Skin, Lung and Radiation Wounds. My laboratory focuses on the understanding the mechanisms that regulate Akt kinase and Protein Kinase A (PKA). Our studies of an inherited mutation for Akt2 protein kinase that causes insulin resistance led to the discovery of a series of molecular switches that regulate Akt dephosphorylation. The implications and importance of this work, as applicable to general protein kinases, was published in PNAS and discussed in perspective articles. More project information found on my Research Site.
Education
PhD University of Calgary, Alberta, Canada 1993
Publications
- AKT inhibition in the central nervous system induces signaling defects resulting in psychiatric symptomatology
- A tripartite cooperative mechanism confers resistance of the protein kinase A catalytic subunit to dephosphorylation
- Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response
- MiR-146a targets Fos expression in human cardiac cells
- A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity