Amit K. Srivastava, PhD
Assistant Professor
Contact
1020 Locust Street
Suite 394A
Philadelphia, PA 19107
215-955-8017
215-955-9170 fax
Amit K. Srivastava, PhD
Assistant Professor
Education
Education
PhD (Biotechnology), G.B. Technical University, Lucknow, UP, India - 2010
MS (Microbiology), A.A.I-Deemed University, Allahabad, UP, India - 2003
Fellowship
Postdoctoral Fellow, Johns Hopkins University, Baltimore, MD
Postdoctoral Researcher, Ohio State University, Columbus, OH
Most Recent Peer-Reviewed Publications
- Recovery after human bone marrow mesenchymal stem cells (hBM-MSCs)-derived extracellular vesicles (EVs) treatment in post-MCAO rats requires repeated handling
- Most recent advances and applications of extracellular vesicles in tackling neurological challenges
- Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
- PET imaging of microglia using PBR28suv determines therapeutic efficacy of autologous bone marrow mononuclear cells therapy in traumatic brain injury
- Apoptosis signal-regulating kinase-1 regulates thrombin-induced endothelial permeability
Awards
- Jerry Johnston Andrew Award for Spinal Cord Research, 2017
- World Molecular Imaging Congress Travel Award, 2014
- The American Society for Neural Therapy and Repair Travel Fellowship Award, 2014
Research & Clinical Interests
A major focus of Dr. Srivastava’s research is the use of extracellular vesicles (EVs) as a therapeutic tool in CNS and traumatic disorders. EVs carry proteins and genetic material that can profoundly modify cellular function and may possess regenerative capabilities. Use of cell derived-EVs presents distinct advantages over the use of cells, as they may be less likely to produce a pulmonary first pass effect after transfusion. Similarly, the possibility to replace cell therapy with EV therapy would overcome the problem of graft rejection, which is always a hurdle in diseases with strong immunological components. Dr. Srivastava’s lab has expertise in isolating EVs in current Good Manufacturing Practice (cGMP) compliant manner. He is also investigating the molecular mechanisms by which EVs modulate cellular function.