James Michael, PhD
Research Assistant Professor
Contact Information
Research Assistant Professor
Education
Postdoctoral Fellowship, Thomas Jefferson University, Philadelphia, PA
PhD, Temple University, Philadelphia, PA
Publications
- Plasma growth factors maintain constitutive translation in platelets to regulate reactivity and thrombotic potential
- Activation of coagulation and proinflammatory pathways in thrombosis with thrombocytopenia syndrome and following COVID-19 vaccination
- Novel Strategy to Combat the Procoagulant Phenotype in Heparin-Induced Thrombocytopenia Using 12-LOX Inhibition
- Species Differences in Platelet Protease-Activated Receptors
- Characteristics of VITT antibodies in patients vaccinated with Ad26.COV2.S
Research & Clinical Interests
A major focus of our research is the investigation of thrombosis, with an emphasis on exploring the bidirectional interactions between platelets and other blood cells. Our current studies are focused mainly on immune thrombotic disorders including heparin-induced thrombocytopenia (HIT), and vaccine-induced immune thrombotic thrombocytopenia (VITT). Our research approaches include the use of de-identified clinical samples, healthy human blood donors, and genetically modified mice in various biochemical assays of cell isolation, activation, and signaling, in addition to novel imaging approaches.