Bin Wang, PhD
Associate Professor, Department of Medicine
Contact Information
Associate Professor, Department of Medicine
Expertise & Research Interests
My lab focuses on investigating the roles of parathyroid hormone (PTH)/PTH related protein (PTHrP)–activated PTH receptor in the diseases of osteoporosis and osteoarthritis.
Project(s):
(1) Characterization of bimodal effects of PTH on bone metabolism. The long-term objective is to identify new compounds that can enhance the anabolic effect of PTH or PTHrP for the treatment of osteoporosis.
(2) Determining whether and how PTHrP plays a pathogenic role in articular cartilage degeneration (osteoarthritis) during aging.
(3) Characterization of the interaction of PTH receptor with other GPCRs. The purpose of this research will illustrate how PTH receptor coordinates with other GPCRs to maintain musculoskeletal homeostasis
Publications
- Metabolic shifts in ratio of ucOcn to cOcn toward bone resorption contribute to age-dependent bone loss in male mice
- New role of calcium-binding fluorescent dye alizarin complexone in detecting permeability from articular cartilage to subchondral bone
- Abaloparatide Maintains Normal Rat Blood Calcium Level in Part Via 1,25-Dihydroxyvitamin D/osteocalcin Signaling Pathway
- Scribble scrambles parathyroid hormone receptor interactions to regulate phosphate and vitamin D homeostasis
- Mutation of Methionine to Asparagine but Not Leucine in Parathyroid Hormone Mimics the Loss of Biological Function upon Oxidation