Dmitry Temiakov, PhD
Professor, Department of Biochemistry & Molecular Biology
Contact
1020 Locust Street
Jefferson Alumni Hall, Room 425E
Philadelphia, PA 19107
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Dmitry Temiakov, PhD
Professor, Department of Biochemistry & Molecular Biology
Expertise and Research Interests
My laboratory uses structural biology in combination with biochemical approaches to study the structure and function of mitochondrial transcription machinery. We are interested in deciphering molecular mechanisms of transcription initiation, elongation, termination and anti-termination, as well as replication primer synthesis by mitochondrial RNA polymerase. We also aim to understand the interplay between transcription and replication machineries in mitochondria of normal and cancer cells.
Publications
- Structural basis for substrate binding and selection by human mitochondrial RNA polymerase
- Structural basis for DNA proofreading
- Molecular basis for maternal inheritance of human mitochondrial DNA
- Mesoscale structure–function relationships in mitochondrial transcriptional condensates
- Mechanisms of mitochondrial promoter recognition in humans and other mammalian species