Timothy Stalker, PhD
Assistant Professor, Department of Medicine
Contact Information
Assistant Professor, Department of Medicine
Expertise & Research Interests
Hemostasis is the physiologic process that stops bleeding following a breach in the vasculature. Disruption of various components of the hemostatic system can have disastrous consequences for humans, including excessive bleeding or hemorrhage when hemostasis is insufficient (e.g. hemophilia, thrombocytopenia, etc), or thrombosis when the hemostatic machinery is activated inappropriately (e.g. myocardial infarction, stroke, DVT/PE). The goal of our research is to gain a better understanding of the mechanisms that regulate hemostasis and thrombosis in vivo. In particular, we are interested in how multiple signaling inputs present at a site of vascular injury are integrated to regulate the cellular and biochemical effectors of the hemostatic system. The following is a brief summary of major ongoing projects.
Publications
- Investigating clot-flow interactions by integrating intravital imaging with in silico modeling for analysis of flow, transport, and hemodynamic forces
- Procoagulant membranes during hemostasis
- Dual antithrombotic therapy dose-dependently alters hemostatic plug structure and function
- Plasma growth factors maintain constitutive translation in platelets to regulate reactivity and thrombotic potential
- Fluorescent peptide for detecting factor XIIIa activity and fibrin in whole blood clots forming under flow