MOLECULAR MECHANISMS OF PHAGOCYTOSIS: HOW DO PATHOGENS SUBVERT THIS PROCESS?
- Unraveling membrane trafficking involved in the phagocytic pathway and its regulation
- How do intracellular bacteria interfere with the host phagocytic system to escape lysosomal degradation?
DO INTRACELLULAR BACTERIA COMMONLY USE SNARE-LIKE PROTEINS TO MANIPULATE THE HOST MEMBRANE FUSION?
- Screening Salmonella and Legionella genomes
- Study the inhibitory effect of potential SNARE-like bacterial proteins
CHARACTERIZATION OF EUKARYOTIC MEMBRANE FUSION MACHINERY
- Identification and characterization of primitive membrane fusion machineries (similar to SNARE proteins)
- Characterization of the specificity of fusion encoded in the SNARE proteins
- Characterization of intramolecular SNARE regulation
STUDY OF THE PHAGOCYTIC MECHANISM IN MAST CELLS, ONE OF THE MAIN PLAYERS IN ALLERGY