Fabienne Paumet, PhD
Professor, Department of Microbiology & Immunology
Co-Director, Immunology & Microbial Pathogenesis PhD Program
Contact Information
Bluemle Life Sciences Building
233 South Tenth Street
Room 750
Philadelphia, PA 19107
Professor, Department of Microbiology & Immunology
Co-Director, Immunology & Microbial Pathogenesis PhD Program
Research & Clinical Interests
MOLECULAR MECHANISMS OF PHAGOCYTOSIS: HOW DO PATHOGENS SUBVERT THIS PROCESS?
- Unraveling membrane trafficking involved in the phagocytic pathway and its regulation
- How do intracellular bacteria interfere with the host phagocytic system to escape lysosomal degradation?
DO INTRACELLULAR BACTERIA COMMONLY USE SNARE-LIKE PROTEINS TO MANIPULATE THE HOST MEMBRANE FUSION?
- Screening Salmonella and Legionella genomes
- Study the inhibitory effect of potential SNARE-like bacterial proteins
CHARACTERIZATION OF EUKARYOTIC MEMBRANE FUSION MACHINERY
- Identification and characterization of primitive membrane fusion machineries (similar to SNARE proteins)
- Characterization of the specificity of fusion encoded in the SNARE proteins
- Characterization of intramolecular SNARE regulation
STUDY OF THE PHAGOCYTIC MECHANISM IN MAST CELLS, ONE OF THE MAIN PLAYERS IN ALLERGY
Publications
- Specialized contact sites regulate the fusion of chlamydial inclusion membranes
- Chlamydia trachomatis Subverts Alpha-Actinins To Stabilize Its Inclusion
- Cross Talk between ARF1 and RhoA Coordinates the Formation of Cytoskeletal Scaffolds during Chlamydia Infection
- Depletion of SNAP-23 and Syntaxin 4 alters lipid droplet homeostasis during Chlamydia infection
- Structural basis for the homotypic fusion of chlamydial inclusions by the SNARE-like protein IncA