Sara Meyer, PhD
Assistant Professor, Department of Cancer Biology
Contact
Featured Links
Sara Meyer, PhD
Assistant Professor, Department of Cancer Biology
Research Interests
Our group is interested in understanding the molecular mechanisms that contribute to myeloid leukemogenesis, with an emphasis on identifying new opportunities for therapeutic intervention. We are currently focused on characterizing how non-coding RNA, including lncRNA and miRNA, promote malignant phenotypes of cell growth, survival, and self-renewal in normal hematopoietic stem cells and leukemia cells. Another main focus of our research aims to better understand the disease mechanisms of a specific subgroup of acute myeloid leukemia (AML) harboring mutations in the epigenetic modifiers DNMT3A and TET2, and how the regulatory action of non-coding RNA impacts the epigenetic state of AML. Importantly, all of our research has a common underlying goal to exploit these mechanisms as possible therapies to induce leukemia cell death and/or differentiation.
Publications
- FLT3 tyrosine kinase inhibition modulates PRC2 and promotes differentiation in acute myeloid leukemia
- Context is key for FLT3-ITD
- miR-196b-TLR7/8 Signaling Axis Regulates Innate Immune Signaling and Myeloid Maturation in DNMT3A-Mutant AML
- KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression Programs
- Genetic heterogeneity and clonal evolution in acute myeloid leukemia