Andrzej Fertala, PhD
Biomet Professor, Department of Orthopaedic Surgery
Contact
1015 Walnut Street
Bluemle Life Sciences Building, Room 430
Philadelphia, PA 19107
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Andrzej Fertala, PhD
Biomet Professor, Department of Orthopaedic Surgery
Expertise and Research Interests
My primary research activities involve the area of extracellular matrix. In particular, my studies focus on (i) identifying pathomechanisms of heritable diseases of connective tissues caused by mutations in collagen genes, (ii) technologies to produce novel collagen-like proteins for biomedical applications, and (iii) developing novel approaches to limit excessive fibrosis.
In the studies on the molecular basis of the heritable diseases caused by mutations in collagenous proteins, my studies place a main emphasis on (i) osteogenesis imperfecta caused by mutations in collagen I, (ii) spondyloepiphyseal displasias caused by mutations in collagen II, and (iii) on epidermolysis bullosa caused by mutations in collagen VII.
In addition to the studies on pathomechanisms of heritable diseases of connective tissues, my work contributed significantly to developing novel technologies for the production of human recombinant collagens for a number of biomedical applications. As animal-derived collagens and gelatin, at present widely used in biomedical and pharmaceutical fields, have the potential to transmit animal-derived diseases, the ability to produce recombinant human collagens and gelatin is very attractive. The high value and the potential applicability of recombinant human collagens are reflected by an approved patent and its licensing by Thomas Jefferson University to a commercial company. In addition to already established technologies, I continue developing new approaches to the rational engineering of collagenous proteins for biomedical applications. In response to the need for novel therapies for fibrotic diseases, my laboratory has recently initiated studies on novel approaches to limit excessive fibrosis. These new approaches are built on my discoveries of processes that govern the formation of collagen fibrils. As this process is fundamental for the formation of fibrotic deposits, my concept is that, by inhibiting the formation of collagen fibrils, it will be possible to limit fibrosis. If experimentally confirmed, this novel concept may lead to developing novel inhibitors of fibrotic processes occurring in keloids, hypertrophic scarring, and others.
Publications
- Evaluating the Efficacy of a Thermoresponsive Hydrogel for Delivering Anti-Collagen Antibodies to Reduce Posttraumatic Scarring in Orthopedic Tissues
- Corneal Wound Healing in the Presence of Antifibrotic Antibody Targeting Collagen Fibrillogenesis: A Pilot Study
- Extracellular Targets to Reduce Excessive Scarring in Response to Tissue Injury
- Scar formation in the presence of mitomycin C and the anti-fibrotic antibody in a rabbit model of glaucoma microsurgery: A pilot study
- Profibrotic behavior of fibroblasts derived from patients that develop posttraumatic shoulder stiffness
Industrial Relevance
Patents:
- Prockop, D.J., L. Ala-Kokko, A. Fertala, A. Sieron, K.I. Kivirikko, A. Geddis, T. Pihlajaniemi, Synthesis of human procollagens and collagens in recombinant DNA systems. U.S. Patent Number 5,405,757, 1995 (Patent licensed by TJU to a biotech company; FibroGen).
- Prockop, D.J., A. Fertala, Inhibitors of collagen assembly. U.S. Patent Number 6,472,504. 2002.
- Fertala, A., F. Ko, Collagen or collagen-like peptide containing polymeric matrices. U.S. Patent Number 6,753,311, 2004.
Keywords
collagen; extracellular matrix; recombinant collagen; fibrosis