John-Paul Vermitsky, PhD
Adjunct Faculty
Contact Information
Jefferson Alumni Hall
1020 Locust Street
Philadelphia, PA 19107
Adjunct Faculty
Education
PhD, Drexel University College of Medicine, Philadelphia, PA, 2006
BS, Drexel University, Philadelphia, PA, 2001
Publications
- Evaluation of polymorphic locus sequence typing for candida glabrata epidemiology
- UPC2A is required for high-level azole antifungal resistance in Candida glabrata
- Flucytosine antagonism of azole activity versus Candida glabrata: Role of transcription factor Pdr1 and multidrug transporter Cdr1
- X-Plate Technology:A new method for detecting fluconazole resistance in Candida species
- Antifungal resistance of Candida glabrata vaginal isolates and development of a quantitative reverse transcription-PCR-based azole susceptibility assay
- Survey of vaginal-flora Candida species isolates from women of different age groups by use of species-specific PCR detection
- Proteomic analysis of experimentally induced azole resistance in Candida glabrata
- Pdr1 regulates multidrug resistance in Candida glabrata: Gene disruption and genome-wide expression studies
- Promoter-dependent disruption of genes: Simple, rapid, and specific PCR-based method with application to three different yeast
- Azole resistance in Candida glabrata: Coordinate upregulation of multidrug transporters and evidence for a Pdr1-like transcription factor
Research Interest
My research interest is understanding the mechanisms of antifungal resistance in pathogenic fungi. Specifically, understanding the transcriptional regulation of drug transporter genes in C. glabrata. In my research we explored the role of PDR1 as the transcription factor regulating CDR1 and PDH1 transporter genes and the role of gain-of-function mutations in both laboratory and clinical isolates.
Biography
I received my education from Drexel University (B.S.) and Drexel University College of Medicine (Ph.D.) in 2001 and 2006 respectively. My doctoral work is focused on molecular biology and genetics, specifically in relationship to the field of microbiology. Since completing graduate school, I have spent most of my career in undergraduate education, starting my career at Camden County College as an adjunct in 2003. However, I did spend 5 years doing basic science research at Medical Diagnostic Laboratories in Hamilton, New Jersey. In 2010, I was hired at Community College of Philadelphia for a tenure-track position in the Department of Biology where I remain as an Associate Professor. In 2015, I started teaching at Thomas Jefferson University as an adjunct in the College of Life Sciences for the P4 program and then in 2017 in the College of Health Professions for the Institute for Emerging Health Professions (formally School of Continuing and Professional Studies). The courses that I teach include General Biology, Anatomy & Physiology I, Anatomy & Physiology II, and Principles of Microbiology.